The distribution of actin inside cells displays spontaneous dynamic behaviors that are similar to those of an excitable medium. The modeling work treats these phenomena with methods including Brownian-dynamics and stochastic-growth simulations, and analytic theory.
The main goals of the modeling are to are to to establish how actin polymerization generates force to "sculpt" the cell membrane in processes such as endocytosis, to pin down the key mechanisms driving migration of cells, to clarify force generation by actomyosin and actin bundles. We are currently expanding our work in mechanobiology to understand how mechanosensitive channels regulate hydration of pollen grains, in collaboration with the Haswell lab at Washington University.
This work is supported by the Center for Engineering Mechanobiology. Scientific Reports 7: The Journal of Neuroscience Carlson BA Differences in electrosensory anatomy and social behavior in an area of sympatry between two species of mormyrid electric fishes.
Journal of Experimental Biology Ma X, Kohashi T and Carlson BA Extensive excitatory network interactions shape temporal processing of communication signals in a model sensory system. Journal of Neurophysiology The Journal of Experimental Biology Carlson BA Diversity matters: The importance of comparative studies and the potential for synergy between neuroscience and evolutionary biology.
Archives of Neurology Science Classical electromagnetism via Maxwell's equations. Electric and magnetic fields from static charge and current distributions. Mathematical techniques for solving electrostatic and magnetostatic problems.
Electrostatic and magnetostatic forces and energies. Classical electromagnetism in macroscopic and microscopic forms; electromagnetic fields of and forces between charged particles. Applications to electrostatic, magnetostatic, electrodynamic, and radiation problems. The course will treat the theoretical foundations of nonlinear dynamics, and its applications to phenomena in diverse fields including physics, biology, and chemistry.
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